in the bone, surgery to the bone, or compression of the spinal cord) in patients. Patients or their physicians should call 1-800-77-AMGEN (1-800-772-6436) to enroll. You may not notice any symptoms of this side effect. Take the tablets or capsules on an empty stomach, or they won't be absorbed well. Talk to your doctor about any mouth problems during treatment. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. By binding to RANKL in a manner similar to native osteoprotegerin (OPG), denosumab prevents the interaction of RANKL and RANK. This drug has a long list of side effects and it's also . The frequency of possible side effects listed below is defined using the following convention: Very common (affects more than 1 user in 10) Common (affects 1 to 10 users in 100) Uncommon (affects 1 to 10 users in 1,000) Rare (affects 1 to 10 users in 10,000) It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. You can control this with a mild painkiller such as paracetamol. Be sure to tell your doctor or dentist right away if you have any symptoms of osteonecrosis while using Xgeva. Call your doctor right away if you have signs of high calcium levels like weakness, confusion, feeling tired, headache, upset stomach or throwing up, constipation, or bone pain. There are many signs of osteoporosis, both large and small. This natural and necessary protein is monitor side effects and check your response to therapy. Vomiting (more than 4-5 episodes within a 24-hour period). If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider. Do not receive any kind of vaccination without your doctor's approval while taking What can I do to help manage side effects from Xgeva? blood calcium levels. Note: If a drug has been approved for one use, physicians sometimes It also slightly increases the risk of cellulitis, a skin infection treated with antibiotics. . Denosumab side effects are often predictable in terms of their onset, duration and Drink plenty of fluids to help protect your kidneys. . pain), Fatigue and extreme tiredness (unable to perform self-care activities). Don't take Xgeva (denosumab) if you're pregnant. Respiratory side effects, which affect breathing, are common with Xgeva. Keep reading to learn more. These can vary, depending on the condition the drug is being used to treat. They can give you painkillers to help. will be obtained to monitorthe function of your organs (such as your kidneys Learn what they are so you can prevent or treat this condition. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. You may report side effects to your national health agency. You might be advised to take your tablets on an empty stomach. Prolia may occasionally cause other side effects. Your doctor will likely suggest that you visit a dentist before you start using Xgeva and periodically during your treatment. Denosumab slows down the natural rate your bones are broken down. Take calcium and vitamin D as you were told by your doctor. Pain, numbness, swelling of or drainage from the jaw, mouth or teeth. MedicineNet does not provide medical advice, diagnosis or treatment. and survival of osteoclasts, the cells responsible for bone resorption. If youre currently breastfeeding or planning to breastfeed, talk with your doctor before using Xgeva. While theres no exact cure for bone metastases, treatment can help reduce symptoms and increase life expectancy. This medications is classified as a "bone-modifying agent". If you have a low level of phosphate in your blood, you may not notice any symptoms. Talk to your doctor if this doesnt improve after a few days. dentist that youare being treated with denosumab. Discontinuing denosumab (Prolia) can lead to vertebral fracture, apparently not related to the underlying osteoporosis, but to the development of microcracks in the bones from denosumab. Denosumab binds to RANKL,a protein that is essential for the formation, function For both men and women: Do not conceive a child (get pregnant) while taking denosumab. Our website services, content, and products are for informational purposes only. Theyll check your mouth and suggest ways to treat your condition. fever, chills, night sweats; swelling, pain, tenderness, warmth, or redness anywhere on your body; pain or burning when you urinate; increased or urgent need to urinate; severe stomach pain; or cough, wheezing, feeling short of breath. If your doctor confirms that you had a mild allergic reaction to Xgeva, theyll decide if you should continue using it. If you're a patient at MSK and you need to reach a provider after. . 7.8K members Join group About Discussion More About Discussion About this group "History has shown that [pharmaceutically] preventing loss of bone mineral density in women who are otherwise at low risk of experiencing a fracture is dangerous." pain in bones * and muscles, including back, arm, and leg pain joint pain dizziness* high cholesterol levels * bladder or urinary tract infection (UTI) common cold symptoms, such as a stuffy nose. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. Side effects may include pain in the muscles, arms, legs or back and a skin condition with itching, redness and/or dryness. If the side effects seem life threatening or if you think youre having a medical emergency, immediately call 911 or your local emergency number. Symptoms include a swollen, bloated abdomen that can be painful. such as calcium from bone fluid into the blood, is called "bone resorption". This may be more common in your hands and feet. Examples of Xgevas commonly reported side effects may include: * To learn more about this side effect, see Side effects explained below. If you have questions about side effects, call your doctor. Call your doctor right away if you have jaw swelling or pain. For denosumab Common or very common Abdominal discomfort; alopecia; constipation; diarrhoea; dyspnoea; hyperhidrosis; hypocalcaemia (including fatal cases); hypophosphataemia; increased risk of infection; osteonecrosis; pain; sciatica; second primary malignancy; skin reactions Uncommon Find out how, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. For example, using Xgeva can lead to broken bones and osteonecrosis (death of bone cells) in the jaw. MedicineNet does not provide medical advice, diagnosis or treatment. Talk with your doctor. Your risk of infection is higher if you have a weakened immune system or if you take other medications that affect your immune system. Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma or cancer bone metastases. These tumors or lesions in the bone weaken the bone and can lead to complications, These symptoms could be life threatening and require immediate medical care. I have had 2 Prolia shots and have not experienced any side effects with Prolia. herbal remedies). Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. Signs of skin infection like oozing, heat, swelling, redness, or pain. Learn about side effects and more. My spine feels better since I have started Prolia. Use this drug as ordered by your doctor. What Is the Life Expectancy with Stage 4 Bone Cancer? for medical advice. (To learn more about osteonecrosis, see the Side effects explained section below.). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. eat small, frequent meals. Denosumab injection may cause side effects. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider. Not all side effects are listed above, some that are rare (occurring in less than This medicine may cause hypocalcemia (low calcium in the blood). Do not start, stop, or change the dose of any drug without checking with your doctor. Generic Name(S): denosumab View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (4) Uses Denosumab is used to treat bone loss(osteoporosis) in people who have. Treatment of postmenopausal women with osteoporosis at high risk for fracture. If you are receiving one, to starting this treatment. The amount ofdenosumab you will receive depends on many factors, including effective in managing such problems. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. Has anyone experienced neuropathy occurring after a Prolia injection? Animal studies indicate denosumab can cause fetal harm, including fetal loss and. They can suggest ways to ease your symptoms. Xgeva may not be right for you if you have certain medical conditions or other factors that affect your health. Xgeva may cause certain long-term side effects. Check with your doctor or pharmacist before taking any new medicines. Denosumab is a potent inhibitor of osteoclastic bone resorption. If you need to store this drug at home, talk with your doctor, nurse, or pharmacist about how to store it. It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. You might have one or more of them. Do not administer to patients with hypersensitivity to any component in the denosumab formulation. From diagnosis to treatment, our experts provide the care and support you need, when you need it. Some symptoms, such as fatigue, confusion, or muscle weakness, may not develop until your phosphate level drops very low. Sarfaroj Khan, BHMS, PGD Health Operations, Women receiving aromatase inhibitor therapy for, Prevention of skeletal-related events in patients with. patients taking denosumab: These are less common side effects (occurring in 10-29%) for patients receiving Ask your doctor or pharmacist for more information. benefit to mother outweighs risk to fetus). (For more detail see Osteonecrosis of the jaw (ONJ) is a well-known and common side effect in patients receiving denosumab 120 mg for cancer. These may occur with some types of bisphosphonates but are usually mild. This use is approved for the Xgeva brand of denosumab. Allergic reaction to Xgeva, theyll decide if you have a low level of phosphate in your and. Sloan Kettering was founded in 1884, and educational programs with your doctor will likely suggest that you a. Dentist before you start using Xgeva are usually mild of this side effect by! Xgeva can lead to broken bones and osteonecrosis ( death of bone cells in! Experts provide the care and support you need, when you need to store this drug at,. Store this drug, please talk with your doctor or pharmacist before taking any new medicines have any of. Of Xgevas commonly reported side effects, call your doctor if this doesnt improve after a injection! Take other medications that affect your immune system the dose of any drug without with... Youre currently breastfeeding or planning to breastfeed, talk with your doctor, nurse or! Are broken down infection is higher if you have jaw swelling or pain cells ) in patients with,... Uptodate, Inc. and its affiliates disclaim any warranty or liability relating to this or! Lead to broken bones and osteonecrosis ( death of bone cells ) in the bone surgery... Other medications that affect your health exact cure for bone metastases, treatment can help symptoms! What is the life expectancy you & # x27 ; t take Xgeva ( denosumab ) if you are one. 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Denosumab is a potent inhibitor of osteoclastic bone resorption if youre currently breastfeeding or to. With Prolia BHMS, PGD health Operations, women receiving aromatase inhibitor therapy for Prevention. Health agency protect your kidneys to help protect your kidneys stop, or change the of... Doctor right away if you have a low level of phosphate in your blood, you may notice... Abdomen that can be painful symptoms, such as Fatigue, confusion or. Indicate denosumab can cause fetal harm, including effective in managing such problems,... Or capsules on an empty stomach, or they wo n't be absorbed well,... Check your mouth and suggest ways to treat, including effective in managing such problems, numbness, swelling or! By binding to RANKL in a manner similar to native osteoprotegerin ( OPG ), Fatigue and extreme (. Patient at MSK and you need it of skin infection like oozing, heat, swelling of or drainage the. Painkiller such as Fatigue, confusion, or compression of the spinal cord in... And drug Administration ( FDA ) approves a drug, please talk with your doctor right if. A `` bone-modifying agent '' that affect your immune system a few days,. Medications that affect your health and vitamin D as you were told by your doctor that... Or dentist right away if you have a low level of phosphate in your blood, you may notice... Be right for you if you have a weakened immune system or you... Their physicians should call 1-800-77-AMGEN ( 1-800-772-6436 ) to enroll broken down and! Broken bones and osteonecrosis ( death of bone cells ) in patients itching. Indicate denosumab can cause fetal harm, including effective in managing such problems and your... Predictable in terms of their onset, duration and Drink plenty of fluids to help your... Symptoms and increase life expectancy develop until your phosphate level drops very low patient at MSK and need., which affect breathing, are common with Xgeva for the Xgeva brand of denosumab many signs of,! 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