Applies only to oral form of both agents. Separate by at least 4 hours. Platelet concentration is measured either manually using a hemocytometer, or by placing blood in an automated platelet analyzer using electrical impedance, such as a Coulter counter. Benefits of combination therapy should be carefully weighed against the potential risks of combination. Dosage Forms & Strengths oral solution. Consider increasing CYP3A substrate dose if needed. Resume previous entrectinib dose after discontinuing moderate CYP3A4 inhibitor for 3-5 elimination half-lives. Applies only to oral form of both agents. sulfamethoxazole will increase the level or effect of eltrombopag by affecting hepatic enzyme CYP2C9/10 metabolism. The initial intravenous immunoglobulin dose of either 0.4 g/kg/day for up to 5 days or, alternatively, a short course of high dose intravenous immunoglobulin (1 g/kg for 1-2 days) has been found to be effective . Applies only to oral form of both agents. (See also Overview of Myeloproliferative read more is platelet overproduction in response to another disorder. Magnesium sulfate is a naturally occurring mineral used to control low blood levels of magnesium. Measurement. Applies only to oral form of both agents. Separate by at least 4 hours. Pediatric . (2.1) If needed, a second dose may be administered at least 2 hours after the initial dose. Approved Uses for PROMACTA (eltrombopag) PROMACTA is a prescription medicine used to treat adults and children 1 year and older with low blood platelet counts due to persistent or chronic immune thrombocytopenia (ITP) when other medicines to treat your ITP or surgery to remove the spleen have not worked or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine. However, safety and efficacy have not been established in children with other conditions. The recommended dose is 50 mg or 100 mg taken orally, as needed. Increase daily dose by 25 mg to a maximum of 75 mg/day. Contraindicated. Eltrombopag (2550 mg) or romiplostim has been used in total 9 patients (22%) in the review for a duration from 5 days to 3 weeks; no adverse events were reported [14, 17, 23, 26]. minocycline. fosamprenavir. Dosage Forms & Strengths injectable solution. Avoid or Use Alternate Drug. infigratinib. eltrombopag will increase the level or effect of simvastatin by Other (see comment). (2.1) The maximum dose in a 24-hour period is 200 mg. (2.1) Severe Hepatic or Severe Renal Impairment: Recommended dose is 50 mg; if needed, a second 50 mg Separate by at least 4 hours. Pediatric patients The following dose adjustments are based on a usual pediatric dose of 10 to 15 mg/kg/dose every 12 hours: GFR 30 mL/minute/1.73 m2 or more: No dosage adjustment needed. calcium gluconate, minocycline. eltrombopag. If coadministration unavoidabole, reduce dose to 200 mg/day for patients aged 12 y or older with BSA >1.5m2. separate dose from antacid by at least 2 hr. Appropriate studies on the relationship of age to the effects of Lactated Ringer's injection have not been performed in the pediatric population. Decrease the daily dose by 25 mg. You may access the InterQual SmartSheet(s) for Adult and Pediatric procedures, durable medical equipment and imaging procedures by logging into the secure provider portal or by calling Peach State Health Plan. Password requirements: 6 to 30 characters long; ASCII characters only (characters found on a standard US keyboard); must contain at least 4 different symbols; If it is near the time of the next dose, skip the missed dose. Contraindicated. 220mg (44mg Fe)/5mL; 300mg (60mg Fe)/5mL; eltrombopag. Direct IV infusion for emergencies (eg, cardiac arrest): Rapid IV dose of 1-2 vials of 50 mL (44.6-100 mEq) initially and continued at a rate of 50 mL (44.6 to 50 mEq) every 5-10 minutes if necessary. Avoid or Use Alternate Drug. Sign Up Pediatric information is approved for AstraZeneca's CRESTOR (rosuvastatin calcium) tablets. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Contraindicated. eltrombopag. >400 x 109/L . MISSED DOSE: If you miss a dose, take it as soon as you remember. Dosage needs to be individualized but initially should start at 10-20 mg/day (Asian/pediatric patients: 5 mg/day) and be guided by the results of cholesterol tests taken 2 to 4 weeks later. Iron is a mineral commonly found in red blood cells, where it helps transport oxygen around the body. calcium carbonate decreases levels of eltrombopag by inhibition of GI absorption. magnesium sulfate decreases levels of minocycline by inhibition of GI absorption. Children 14 to 18 years of age40 mg once a day. Separate by at least 4 hours. a substrate of BCRP and P-gp efflux transporters. minocycline. Eltrombopag 75 mg QD, 5 days: 10 mg: 1.6 No effects on sexual development, testicular and epididymal appearance or fertility were observed at either dose level. The following dose adjustments are based on a usual recommended dose in pediatric patients of 5 to 20 mg/kg/day (trimethoprim component) divided every 6 to 12 hours [32569]: CrCl more than 50 mL/minute/1.73 m2: No dosage adjustment needed. fostamatinib 1250mg (elemental calcium 500mg per 5 mL) eltrombopag. Applies only to oral form of both agents. Cases of overdose from doses ranging from less than 1 g to 18 g have been reported with diltiazem, with several cases involving multiple drug ingestions resulting in death. GFR 10 to 29 mL/minute/1.73 m2: 10 to 15 mg/kg/dose IV/PO every 18 hours. eltrombopag. fosamprenavir will increase the level or effect of rimegepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Indicated for adult and pediatric patients with acute lymphoblastic leukemia (ALL) as part of a combination chemotherapy regimen . In certain pediatric populations, zinc supplementation may help reduce et al. Limit simvastatin dose to no more than 10 mg/day and dilitazem dose to no more than 240 mg/day when used concurrently. Stop PROMACTA; increase the frequency of platelet monitoring to twice weekly. Most adult patients will relapse after initial treatment (or are refractory to first-line therapy) and require second-line therapy. Limit your alcohol intake and avoid drinking more than two glasses of alcohol per day while you are taking rosuvastatin. Vincristine single dose along with TP-RA was used in one case due to lack of response to first-line therapies, including IVIG and GC . eltrombopag. Pediatric . Children 8 to 13 years of age20 mg once a day. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Adult Pediatric. Reactive thrombocytosis Reactive Thrombocytosis (Secondary Thrombocythemia) Reactive thrombocytosis is an elevated platelet count (> 450,000/mcL [> 450,000 10 9 /L]) that develops secondary to another disorder. Applies only to oral form of both agents. Acute otitis media in pediatric patients due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae. calcium gluconate decreases levels of eltrombopag by inhibition of GI absorption. Either decreases levels of the other by inhibition of GI absorption. The recommended dose of UBRELVY is 50 mg or 100 mg taken orally with or without food. 400 mg dose: Infuse IV over 2.5 hr; Pediatric. Dosage Forms & Strengths suspension, oral. CrCl 30 to 50 mL/minute/1.73 m2: 5 to 7.5 mg/kg/dose every 8 hours. Avoid repeating dose within 48 hr if coadministered with moderate CYP3A4. {{configCtrl2.info.metaDescription}} Sign up today to receive the latest news and updates from UpToDate. There are many causes, including acute Store at controlled room temperature magnesium hydroxide decreases levels of eltrombopag by inhibition of GI absorption. or 150450 10 9 per liter. InterQual is a nationally recognized evidence-based decision support tool. Iron supplements are probably safe for most people when taken at the recommended dose, though they can cause side effects. Adult Pediatric Geriatric. Avoid repeating rimegepant dose within 48 hr if coadministered with a moderate CYP3A4 inhibitor. Avoid or Use Alternate Drug. A dose of 360 mg/kg resulted in lethality in monkeys. entrectinib and fluvoxamine both increase QTc interval. Contraindicated. calcium citrate decreases levels of eltrombopag by inhibition of GI absorption. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of methotrexate for the treatment of acute lymphoblastic leukemia and polyarticular juvenile idiopathic arthritis in children. eltrombopag. Use of BCRP and/or P-gp only inhibitors (e.g., quinidine, carvedilol, eltrombopag, curcumin) may increase the exposure of ubrogepant Safety and effectiveness in pediatric patients have not been established. UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Magnesium sulfate injection is also used for pediatric acute nephritis and to prevent seizures in severe pre-eclampsia, eclampsia, or toxemia of pregnancy.. Magnesium sulfate is available under the following different brand names: MgSO4. If you miss a dose of this medicine, take it as soon as possible. Adult Pediatric. 200 x 109/L to 400 x 109/L at any time . Children and adolescents ; 60 kg: 10-15 mg/kg/dose PO q4-6hr prn; not to exceed 15 mg/kg/dose or 1,000 mg/dose, whichever is less or 75 mg/kg/day or 4,000 mg/day, whichever is less Fixed dosing 6 years: Ask a healthcare provider Wait 2 weeks to assess the effects of this and any subsequent dose adjustments. magnesium sulfate decreases levels of eltrombopag by inhibition of GI absorption. eltrombopag. Single dose (opioid naive patients): 0.1-0.3 mg single dose, plus available infusion of naloxone; dosage range per manufacturer, is 0.2-1 mg/day; because repeated IT injections are not recommended, alternative route should be used if pain recurs within 24 hours; Continuous infusion (opioid naive patients): 0 .2-1 mg on lumbar region over 24 hr Children younger than 8 years of ageUse and dose must be determined by your doctor. Applies only to oral form of both agents. Applies only to oral form of both agents. Indications for PROMACTA (eltrombopag) PROMACTA is indicated for the treatment of thrombocytopenia in adult and pediatric patients 1 year and older with persistent or chronic immune thrombocytopenia (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. Undiluted: Administer by slow IV injection over 5 minutes; Diluted solutions: Administer IV over 5-60 minutes; Storage 300mg/5mL; tablet. magnesium hydroxide will decrease the level or effect of infigratinib by inhibition of GI absorption. 150mg/mL; oral solution. CrCl less than 10 mL/minute: Administer 50% of the regular dose. The normal range (99% of population analyzed) for platelets in healthy white people is 150,000 to 450,000 per cubic millimeter (a mm 3 equals a microliter). ferrous sulfate decreases levels of eltrombopag by inhibition of GI absorption. Missed Dose . Your doctor may adjust your dose if needed. The intravenous LD 50 is 60 mg/kg in mice and 38 mg/kg in rats. Approved Uses and Important Safety Information. An iron deficiency can cause anemia and fatigue that can be treated and prevented with supplements. Diluted solutions: Infuse over at least 2 hr (not to exceed 1 mEq/kg/hr) Storage Unused vials. Applies only to oral form of both agents.

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