} Abstract Background: Romiplostim, a thrombopoietin receptor agonist (TPOra), is a second-line medical treatment option for adults with chronic immune thrombocytopenia (ITP). PrescriptionGiant does not charge you membership fees or collect your personal information. FDA Approves Nplate for Long-Term Treatment of Adult Chronic ITP. Your doctor will probably start you on a low dose of romiplostim injection and adjust your dose, not more than once every week. Romiplostim is a prescription medicine used to treat low blood platelet counts ( thrombocytopenia) in: adults with immune thrombocytopenia (ITP) when certain medicines or surgery to remove your spleen have not worked well enough. } catch (err) { This website uses cookies to improve your experience while you navigate through the website. var topOffsetForMinScroll = 0; .layout-column--teaser-video-row { width: 50%; padding: 0 10px; } Do notpoolunused portions . .text-material-flex { display: flex; margin-bottom: 1rem; } .footer-top-txt .hpra { h4.accordion-heading { font-size: 1rem!important;} 1 .popup-overlay { position: fixed; top: 0; right: 0; bottom: 0; left: 0; padding: 0 10px; opacity: 1; transition: opacity 0.15s, top 0s; background: rgba(0, 0, 0, 0.7); z-index: 200; display: none; } .owl-carousel .item:hover figure.slider_figure::before { background-color: rgb(0 113 206 / 0.6); } if (currentPathName !== "/honesty-box") { .material-type.nplate-type-pdf { min-height: 9.3rem;} items: 4, National Cancer Institute. a.btn.btn-primary.nplate-btn.video-btn.material { margin: 0;} }, 2000); Ways to Save on Romiplostim Here are some ways that may lower the cost of your Nplate prescription. var currentVideo = currentPopUp.find("video")[0]; Romiplostim comes as a powder that is mixed with liquid prior to injection and is given once a week. The amount of Romiplostim that you will receive depends on many factors, including your height and weight, and your general health or other health problems. } else { 2. .banner-img.nplate-banner-img {margin-top: 1rem;} ul.arrow-list.arrow-list--footer { margin: 3rem 0 1rem; } .banner-txt { width: 60%; padding-top: 0;} } var isClose = true; Tell your doctor if you are breast-feeding. Romiplostim injection may cause changes in your bone marrow. .layout-row.layout-row--honestybox .layout-column--honestybox:nth-child(2) a.btn.btn-primary { background: #88c765; border-color: #88c765; } else return results[1]; 4. //add more offset if there are more than 2 links topOffsetForMinScroll += $(".header").height(); } Fust K, et al. .text-material-flex .text-section { width: 100%; padding: 0 30px;} ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. var isHcp = sessionStorage.getItem("isHcp"); .text-material-flex .text-section { width: 100%; padding-left: 0; } The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. At the time of approval in 2008, experience with both Nplate and Promacta was limited, and safety concerns led to a decision to require a REMS that included restricted distribution and additional safety data collection requirements for each drug to ensure that the benefits of the drugs outweighed their risks. } videojs.getPlayer(players[i].id()).currentTime(0); .pil-teaser.patient-teaser { background-color: #08486a; position: relative; max-width: 1200px; margin: auto; padding: 5rem 6rem 4rem;} This site is designed to provide patients who have been prescribed Nplate (romiplostim) with information about their treatment and other useful materials. .p.blue-teaser-heading {color: #005480;} Romiplostim. var queryParameterKey = "dphonestybox"; Romiplostim FDA approval was expanded once again on October 19, 2019, for the treatment of newly diagnosed or persistent ITP in adults who do not respond to treatment with corticosteroids, immunoglobulins, or splenectomy. while (temp.firstChild) { } Your doctor or pharmacist will give you the manufacturers patient information sheet (Medication Guide) when you begin treatment with romiplostim injection. .teaser-stage { height: 28rem; background:#fff0ed; margin-bottom: 0;} .close-btn { position: absolute; top: -12px; right: -12px; cursor: pointer; border-radius: 50%; padding: 3px 10px; font-weight: 700; color: #fff; background: #b90000; border: none; } We also use third-party cookies that help us analyze and understand how you use this website. .accordion_labels::before { font-size: 1rem;} The reconstituted Nplate solution should be clear and . // Assign this player to a variable . Nplate Platelet Booster | Nplate (romiplostim) INDICATIONS Nplate is a prescription medicine used to treat low blood platelet counts (thrombocytopenia) in: adults with immune thrombocytopenia (ITP) when certain medicines or surgery to remove your spleen have not worked well enough. } else { //store the current path in the session storage so that it can be used to redirect to this page after the honesty box is clicked } .footer_logo { width: 150px; } @media(max-width:1024px){ @media (min-width:700px) { .teaser-stage { margin-bottom: 4rem; } .owl-nav .owl-prev { left: -30px; } nextDot.trigger("click"); You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. color: #2dbcb6; //handle next click scrollToContainer("#" + elementID); ROMIPLOSTIM (roe mi PLOE stim) helps your body make more platelets. - Store intact vials at 2C to 8C (36F to 46F) - Do not freeze. /*Adding Favicon*/ Your doctor will order. /*******media queries****************/ footer a { font-size: 0.9rem; color: #fff; } August 2018. .h1, h1, .h2, h2, .h3, h3, .h4, h4, .h5, h5 { font-family: MyriadProRg, Helvetica, sans-serif; } .popup-open { cursor: pointer; } .material-text a.btn.btn-primary.download { background: #ec951a; border-color: #ec951a; padding: 0.5rem 2rem; border-radius: 36px; min-height: auto; line-height: 1; text-transform: none; } The romiplostim half-life ranges from 1 to 34 days, with the median half-life being 3.5 days. var totalLinks = $(".repatha-link li").length; @media (max-width:768px) { Your doctor will probably start you on a low dose of romiplostim injection and adjust your dose, not more than once every week. Amgen Inc. All rights reserved | IE-NPL-1020-00001 May 2021 Amgen Ireland Ltd - 21 Northwood Court, Santry, Dublin 9, Ireland, .carousel-wrap { margin: 90px auto; padding: 0 5%; width: 80%; position: relative; max-width:1200px;} It works by causing the cells in the bone marrow to produce more platelets. video.removeClass("vjs-controls-disabled"); A healthcare provider will give you this injection. // Assign and event listener for play event Romiplostim injection may cause other side effects. The romiplostim FDA approval was based on the medications ability to produce high overall platelet response rates. In case of overdose, call the poison control helpline at 1-800-222-1222. Romiplostim injection may cause your platelet level to increase too much. .layout-column--teaser-video-row { width: 24.5%; } .material-type.nplate-type-read { min-height: 9rem;} // if ($(this).hasClass("vjs-has-started")) footer { background: #d3e4f2; padding-top: 3.5em; padding-bottom: 2em; color: #333;} A second patient who had an unconfirmed increase in blasts during the extension had received 750 g romiplostim biweekly . .banner-txt { width: 60%; } You should not breast-feed during your treatment with romiplostim injection. Romiplostim injection is given to decrease the risk that you will experience severe bleeding, but there is still a risk that bleeding may occur. { .banner-title { font-size: 2.3rem; color: #005480; margin-bottom: 1rem; } var halfWindowWidth = $(window).height() * 0.5; Nplate (romiplostim) for injection is supplied as a sterile, preservative-free, solid white lyophilized powder in single-dose vials that deliver 125 mcg (NDC . The product's dosage form is injection, powder, lyophilized, for solution and is administered via subcutaneous form.This product is billed for "EA" each discreet unit and contains an estimated . controlBar.find(".vjs-duration").css("display", "block"); Romiplostim injection does not work for everybody. .honestybox img { width: 70%; margin: 0 auto; } As the injection volume may be very small, use a syringe with graduations to 0.01 mL. .home-img .home-img-flex .right-txt { width: 100%; } items: 1, Side effects can be reported directly to the Health Products Regulatory Authority (HPRA) using the available methods via. .p { font-size: 1rem; color: #191e22; margin-bottom: 1rem; } // event.preventDefault(); This video provides a step-by-step guide for adult patients on the NPLATE (ROMIPOSTIM) NPLATE is a prescription medicine used to treat low blood platelet counts (thrombocytopenia). The content should not be used as a substitute for professional medical advice, diagnosis, or treatment. .footer .layout-row--equal-width-columns>.layout-column:nth-child(3) { width: 25%; } Prior to injection, a complete blood count (CBC) is obtained, as the dosage is dependent on the individual's body weight and platelet count at the time of treatment. //for chapter split of single video How long does romiplostim stay in the system? Patients were administered Romiplostim by SC injection once weekly for up to 3 years. Click the CARD below to print or take a screenshot on your mobile phone or tablet. A rise in platelet count generally does not become notable until five days after a dose of romiplostim. .banner-txt.nplate-banner-txt { padding-bottom: 32px; padding-top: 35px;} romiplostim injection is used to increase the number of platelets (cells that help the blood to clot) in order to decrease the risk of bleeding in adults who have immune thrombocytopenia (itp; idiopathic thrombocytopenic purpura; an ongoing condition that may cause easy bruising or bleeding due to an abnormally low number of platelets in the .teaser--video:hover .btn.video-btn { color: #ffffff; } Confounding by underlying medical conditions in the treated patient population made the adverse event data collected by the REMS programs challenging to interpret. .banner-img { width: 100%; margin: 1rem auto; } 1000: { - If needed, unopened vials may be stored in the original carton at room temperature up to a maximum of 25C (77F) for a single period of up to 30 days. } (1, 4), Romiplostim injection can be administered in the outer part of the upper arm, the front of the middle thighs, or into a section of the abdomen located at least two inches away from the navel. . Peak platelet counts occur between days 12 and 14 with a decline to baseline by day 28. prevItem.unbind("click").click(function () { .pil-teaser.patient-teaser::before {position: absolute; left: 50%; width: 8rem; height: 5rem; background-image: url(/-/media/project/agc_ie/icons/nplate-tip.png); content: ''; display: block; background-repeat: no-repeat; background-size: 100%; transform: translate(-50%); top: 0px; } myPlayer = this; .material-section.nplate-video { margin-top: 69px;} var offsetHeight = Math.min(headerHeight, halfWindowWidth); Romiplostim is in a class of medications called thrombopoietin receptor agonists. right: 0; .h1, h1, .h2, h2, .h3, h3, .h4, h4, .h5, h5 { text-align:center; } top: 0px; Pharmacology: Half-life of Drugs. } }); At the beginning of your treatment, your doctor will order a blood test to check your platelet level once every week.Your doctor may increase your dose if your platelet level is too low. } .honestybox { background: #fff; padding: 0; border-radius: 10px; } var nextItem = currentParent.find(".owl-next"); MedlinePlus. 3. .home-img .home-img-flex .left-img { width: 100%; } .unbind("click") .owl-nav div { display: block; background: #0072ce; width: 40px; height: 40px; transition: background .3s ease, opacity .3s ease; position: absolute; top: 50%; -webkit-transform: translateY(-50%); transform: translateY(-50%); font-weight: bold; color: #ffffff; text-align: center; } try{ nextItem.unbind("click").click(function () { .footer-top-txt .p { font-size: 0.9rem; } topOffsetForMinScroll * topOffsetMultiplierDesktop; } Romiplostim injection is also used to treat acute radiation syndrome in patients who have been exposed to high levels (myelosuppressive doses) of radiation. var topOffsetMultiplierLandScape = 1.6; See Prices Manufacturer Coupon Pay as little as $0 for your first fill and $5 for each refill, with insurance. .footer .arrow-list_item::before { background-position: 100% 51.71041%; } (13, 14). .footer_logo { width: 35%; margin-bottom: 1rem; } setTimeout(function () { .h2::after, h2::after { display: none; text-transform: none; } $(this).parent().addClass("vjs-has-started"); Healthcare professionals and patients should be aware, however, that serious risks still exist with Nplate and Promacta. } The romiplostim price varies widely based on factors including dosage, duration of treatment, geographic location, and insurance coverage. A guide that provides you with information about self-injection including a complete step-by-step guide on how to self-inject. .footer-top-txt { padding: 2rem 1rem;} .teaser--video:hover * { color: #0071ce; } // Create array for player IDs Gently swirl and invert the vial to reconstitute. .owl-item figure.slider_figure { margin: 0; position: relative; } currentVideo.play(); It is important that you do not try to give yourself the injection unless } .text-material-flex .text-section { padding-left: 19px; } var topOffsetMultiplierMobile = 1.2; .footer .layout-row--equal-width-columns>.layout-column:first-child { width: 100%; padding-right: 13px; } Romiplostim is in a class of medications called thrombopoietin receptor agonists. } //check if the session storage of isHcp exists or not Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet. .banner-title.kerning { letter-spacing: 1.5px; font-weight: bold;} (21, 22). .unbind("click") var currentHash = location.hash; } Your doctor will monitor your platelet level carefully during your treatment with romiplostim injection. h4.accordion-heading { margin-bottom: 0.5rem;} Avoid excess or vigorous agitation: DO NOT SHAKE. View romiplostim drug monograph Navigate to section Powder for solution for injection Powder and solvent for solution for injection There can be variation in the licensing of different medicines containing the same drug. .repatha-link {top: 100px!important;} /**********Footer-Top**********/ What are the side effects of Romiplostim? name = name.replace(/[\[]/, "\\[").replace(/[\]]/, "\\]"); OncoLink. romiplostim 250 MCG Injection is usually given after other medications have been tried without successful treatment of symptoms. Generally, dissolution of Nplate takes less than 2 minutes. Before sharing sensitive information, make sure you're on a federal government site. Myelosuppression is a bone marrow problem that can lead to a decrease in blood cell counts. Your doctor will probably start you on a low dose of romiplostim injection and adjust your dose, not more than once every week.Romy Injection helps in controlling bleeding by speeding up blood clotting. }, //function for scroll to location.href = $(this).attr("href"); //to make next page button move to next page .layout-column--honestybox { width: 100%; } catch(err){console.log("could not use native pause method");} .material.nplate-video1 { width: 80%;} .block__700bottom { padding-bottom: 30px;} loop: false, (1, 15), A study published in 2012 found that switching from romiplostim to eltrombopag or vice versa may be beneficial for patients with immune thrombocytopenia (ITP) who do not respond to or have adverse effects with the first treatment. /*********Text Material Flex**********/ position: initial; Healthcare professionals should continue to report adverse events involving Nplate or Promacta to the FDA MedWatch program, using the information at the bottom of the page in the "Contact Us" box. .text-material-flex { display: flex; margin-bottom: 1rem; padding: 40px; padding-top: 80px;} if (currentPathName !== "/honesty-box") { }, .patient-resources::before { Romiplostim injection is used to increase the number of platelets (cells that help the blood to clot) in order to decrease the risk of bleeding in adults who have immune thrombocytopenia (ITP; idiopathic thrombocytopenic purpura; an ongoing condition that may cause easy bruising or bleeding due to an abnormally low number of platelets in the blood). Romiplostim may be given by subcutaneous (the layer between the skin and muscle) injection. Risk Evaluation and Mitigation Strategies (REMS) that included elements to assure safe use (ETASU) were required for both Nplate and Promacta at the time of approval because potential serious risks were not well characterized due to the absence of long-term safety data, and FDA determined that the ETASU were necessary to ensure that the benefits of the drugs outweighed their risks. //code to override the behaviour of collapsible transitions or accordian click handler Colony-stimulating factors stimulate the production of blood cells and enhance their functioning. .layout-column--footer-copyright p { margin-bottom: 1rem; } If your platelet level is too high, your doctor may decrease your dose or may not give you the medication at all. Indications and dose Chronic immune (idiopathic) thrombocytopenic purpura in patients refractory to other treatments (such as corticosteroids or immunoglobulins) (under expert supervision) For a list of possible side effects, please see. a.btn.btn-primary.nplate-btn.video-btn { margin: 29px 0px 0px 74px;} //handle prev click .banner-img { width: 40%; margin-left: auto; } topOffsetForMinScroll = This medication is injected under the skin by a health care professional, usually once a week. You can find step by step instructions on how to inject Nplate. " ", Patients should report serious side effects from the use of Nplate or Promacta to the FDA MedWatch program, using the information at the bottom of the page in the "Contact Us" box. IndiaMART. The site is secure. var topOffsetMultiplierDesktop = 1.3; November 2012. head.appendChild(temp.firstChild); .layout-row.layout-row--honestybox { display: block; padding: 0; text-align: center; } Quick guide to home administration of Nplate. $("html, body").animate( }, romiplostim side effects. @param{name{string}} .block700.honesty-bottom .p { font-size: 0.9rem; } .para{color:#fff;} console.log("start time is not there for the video"); currentVideo.pause(); var offsetHeight = headerHeight; The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". preparation and self-administration of the correct dose of Nplate. a .btn btn-primary icon-right icon-arrow-right-white read{background-color:#D34D2F;} var elementID = $(this).attr("href").split("#")[1]; .banner { display: -webkit-box; display: -moz-box; display: -ms-flexbox; display: -moz-flex; display: -webkit-flex; display: flex; flex-direction: row; } On This Page Indications and Usage Dosage and Administration Dosage Forms and Strengths Contraindications Warnings and Precautions Adverse Reactions/Side Effects Platelets are a type of blood cell needed to form blood clots and prevent bleeding. a.btn.btn-primary.nplate-btn.video-btn { width: 189px; border-radius: 44px; padding-right: 3rem; position: relative; margin: 29px 0px 0px 92px; text-transform: none;} //check if the isHcp session key exists or not // Define the ready event for the player Romiplostim and eltrombopag are both thrombopoietin receptor agonists and are used to increase the production of platelets. Used to try to keep the platelet count about 50,000 per microliter in order to lower the risk for bleeding. .banner-btn a.btn.btn-primary { font-size: 0.9rem; } .owl-nav > div { margin-top: -26px; position: absolute; top: 50%; color: #cdcbcd; } }); var startTime = parseInt(currentPopUp.data("start")); .material-heading.nplate-material-heading { margin-top: 50px;} .has-js .external-link-helper_dialog p.dialog-type-dependent img { width: 25%; display: inline-block; margin-bottom: 0; } } Smith Y. .block700.honesty-bottom { margin-bottom: 8rem; } Actual product appearance may differ slightly. $(function () { $("video").on("play", function () { // +++ Determine the available player IDs +++// FDAs review has indicated that some of the adverse events of concern with Nplate and Promacta can be part of the natural history of ITP and other serious underlying medical conditions in patients treated with these drugs. var head = document.head; .footer-top-container { background-color: #cce3f5; } Reconstitute Nplate with Sterile Water for Injection, USP. February 2020. Drug Label Information. .references a {word-break: break-word;} } Khellaf M, et al. ul.arrow-list.arrow-list--footer { margin: 0; } var results = regex.exec(window.location.href); }); The mat lists all the materials you will need to self-inject Nplate, Step-by-step guide to preparation and administration of the Nplate, An illustrated guide to the preparation and self-injection of Nplate, Self-administration diary for adult patients, This booklet will help you to keep a record of the doses of Nplate, Step-by-step guide: preparation and self-administration of the Nplate, A video showing you how to prepare and self-inject Nplate, If you get any side effects, talk to your doctor, pharmacist or nurse. Nplate (romiplostim) is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines . .banner-txt.nplate-banner-txt { width: 100%;} .teaser--video h4 { font-size: 1.2rem; } Switching From Romiplostim to Eltrombopag or Vice Versa for Immune Thrombocytopenia: Efficacy and Safety in 46 Patients. (1, 2, 10, 11), From the community: either rec'd a platelet infusion or they gave him an injection of Romiplostim to stimulate platelet production in his marrow - Inspire member, Romiplostim is administered as a subcutaneous (under the skin) injection by a nurse or doctor at a medical facility. Romiplostim is produced by recombinant DNA technology in Escherichia coli (E coli). .owl-dots .owl-dot { display: inline-block; width: 15px; height: 15px; background: #cce3f5; transition: background .3s ease; border-radius: 50%; margin: 0 0.5rem; } Romiplostim injection is used to increase the number of platelets enough to lower the risk of bleeding, but it is not used to increase the number of platelets to a normal level. $(function () { .video-slider-bg1 .carousel-wrap { margin: 1rem auto;} 0: { .popup-container .embed-wrapper { margin-bottom: 0; } Keep receiving the medication as directed. .has-js .external-link-helper_dialog { width: 75%;} .footer-top-txt { max-width: 1024px; margin: 0 auto; padding: 2rem; text-align: center; } } .download-flex { display: -webkit-box; display: -moz-box; display: -ms-flexbox; display: -moz-flex; display: -webkit-flex; display: flex; flex-direction: row; flex-wrap: wrap; max-width: 1000px; margin-bottom: 2rem; padding-bottom: 2rem; margin: 0 auto;} Romiplostim is produced by recombinant DNA technology in Escherichia coli ( E. coli ). isClose = !isClose; Since 2008, FDA has continued to monitor the safety of Nplate and Promacta, and to evaluate the REMS. .material-text a.btn.btn-primary.read::after { content: ''; background-image: url(/-/media/project/agc_ie/icons/right-arrow-yellow.png); width: 15px; height: 12px; position: absolute; right: 2rem; background-repeat: no-repeat; top: 10px; } Two vial presentations are available, which contain a sufficient amount of active ingredient to provide either 250 mcg or . National Cancer Institute. .banner-title { font-size: 1.5rem; } .has-js .external-link-helper_dialog { width: 90%;} As the volume is small, a syringe with 0.01 mL gradations should be used. console.log("seting the session"); .owl-nav { .teaser-stage { height: 33%; } Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors. It will guide you, step by step, through the self-injection process - and demonstrate how, with practice, injecting can become a routine part of your life. var prevItem = currentParent.find(".owl-prev"); Patients should read the Medication Guide that they get along with their Nplate or Promacta prescription. article.teaser.teaser--video { cursor: pointer; display: block; } .has-js .external-link-helper_button { width: 72%;} //only for mobile devices var topOffset = What are the side effects of romiplostim? videojs(videoJsId).ready(function () { var players = []; If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button. Complete periodic safety forms for patients receiving Nplate or Promacta.

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