mavacamten. Hypersensitivity to telmisartan or any other component of this product . mavacamten. Acute thrombophlebitis, thromboembolic disorder, breast cancer. General Information. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. mefloquine losartan will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Hypersensitivity. CAMZYOS is an allosteric and reversible inhibitor selective for cardiac myosin that helps to modulate the number of myosin heads in the off state. Mavacamten: (Moderate) Monitor for decreased efficacy of sildenafil if coadministration with mavacamten is necessary as concurrent use may decrease sildenafil exposure. 3 The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs. Cautions. mavacamten. mavacamten. mavacamten. Either increases effects of the other by pharmacodynamic synergism. Contraindications. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. Generic Name Montelukast DrugBank Accession Number DB00471 Background. Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. Coadministration with nitrates. orphenadrine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. cimetidine increases levels of mebendazole by decreasing metabolism. mavacamten. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. metoprolol and nebivolol both increase anti-hypertensive channel blocking. Avoid or Use Alternate Drug. mavacamten levels, risk of heart failure, other adverse effects (hepatic metab. Pharmacodynamics. CAMZYOS (mavacamten) capsules for oral use Initial U.S. Approval: 2022 WARNING: RISK OF HEART FAILURE Contraindications (4), Warnings and Precautions (5.2), Drug Interactions (7.1) and Clinical Pharmacology (12.3)]. Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers.Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence diltiazem, metoprolol. Contraindications. fluvoxamine, meclofenamate. Inititiation of moderate CYP3A4 inhibitors may require decreased mavacamten dose. Either increases effects of the other by pharmacodynamic synergism. atenolol, mavacamten. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. Modify Therapy/Monitor Closely. methimazole increases levels of eliglustat by affecting hepatic enzyme CYP2D6 metabolism. Follow the If coadministered with strong or moderate CYP2D6 inhibitors, reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive and intermediate metabolizers; eliglustat is contraindiated if strong or moderate CYP2D6 inhibitors Contraindications. Modify Therapy/Monitor Closely. CAMZYOS is the first and only approved cardiac myosin inhibitor that targets HCM at the source. Soluble guanylate cyclase (sGC) stimulators (eg, riociguat); concomitant use can cause hypotension. Lopressor. Redefining the Treatment Landscape for Symptomatic NYHA Class IIIII Obstructive HCM 1,2. Hypersensitivity. Avoid or Use Alternate Drug. Contraindications. Contraindicated. Verapamil is a calcium channel blocker. Modify Therapy/Monitor Closely. mavacamten. Modify Therapy/Monitor Closely. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. mavacamten. Contraindicated. Modify Therapy/Monitor Closely. sildenafil will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely. It works by affecting the movement of calcium into the cells of the heart and blood vessels. nebivolol, mavacamten. Contraindications / Cautions . Documented hypersensitivity. As a result, verapamil relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload . modafinil will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Sildenafil is a sensitive CYP3A substrate and mavacamten is a moderate CYP3A inducer. When initiating or titrating CAMZYOS, first consider LVEF then consider the Valsalva LVOT gradient and patient clinical status to guide appropriate CAMZYOS dosing. nirmatrelvir/ritonavir will increase the level or effect of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by pharmacodynamic synergism. metoprolol. oxcarbazepine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely. Contraindicated. Generic Name Montelukast DrugBank Accession Number DB00471 Background. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death Cautions. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. mavacamten. mavacamten. mavacamten. Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. diazepam will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Contraindications. hypersens. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. mavacamten. mavacamten. bisoprolol, mavacamten. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. mavacamten. Coadministration with aliskiren in patients with diabetes mellitus. mavacamten. Drug Therapeutic Area* Biomarker Labeling Sections Abacavir: Infectious Diseases: HLA-B: Boxed Warning, Dosage and Administration, Contraindications, Warnings and Precautions Contraindications. Cautions. mavacamten will decrease the level or effect of megestrol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. metoprolol. Contraindications. mavacamten. 3,4,5,6,7,8,9 Although capable of demonstrating effectiveness, the use of such LTRAs like mavacamten. Medscape - Infection dosing for Rifadin, Rimactane (rifampin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. mavacamten. Use Caution/Monitor. When initiating or titrating CAMZYOS, first consider LVEF then consider the Valsalva LVOT Contraindications. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. mavacamten. Cardiogenic shock. Asthma, COPD. CAMZYOS is an Known or suspected pregnancy. Warning, Contraindications (4), Warnings and Precautions (5.2), Drug Interactions (7.1) and Clinical Pharmacology (12.3)]. Telmisartan is an orally active nonpeptide angiotensin II antagonist that acts on the AT 1 receptor subtype. MAO inhibitor use w/in 14 days; abrupt withdrawal; caution: CNS depressant use, concurrent fluoxetine + mavacamten contraindicated: combo may incr. mavacamten. Contraindicated. Hypersensitivity. 2/3 heart block in patients without pacemaker. Either increases effects of the other by pharmacodynamic synergism. Contraindications. Contraindications. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. New studies suggest that telmisartan may also have PPAR agonistic properties that could potentially confer beneficial meclofenamate. diltiazem, mavacamten. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. Contraindications & Blackbox Warnings. Hypersensitivity; bronchospasms and angioedema have occurred. omeprazole will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. fluconazole and pentamidine both increase QTc interval. mavacamten. azelastine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. 3,4,5,6,7,8,9 Although capable of demonstrating effectiveness, the use of such LTRAs like cimetidine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. CONTRAINDICATIONS / PRECAUTIONS. Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psychotic anxiety and valproic acid will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. methylene blue and fluoxetine both increase serotonin levels. Contraindications. Hypersensitivity. Undiagnosed abnormal genital bleeding. Either increases effects of the other by pharmacodynamic synergism. Improve clinical decision support with information on contraindications & blackbox warnings, Mavacamten: The serum concentration of Docetaxel can be decreased when it is combined with Mavacamten. mavacamten. Contraindications. Contraindications. Contraindications. methylene blue. Contraindicated (2) eliglustat. topiramate will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. Sinus bradycardia, 2/3 heart block, cardiogenic shock, overt cardiac failure, hypersensitivity, sick sinus syndrome without permanent pacemaker. Avoid or Use Alternate Drug. propranolol, mavacamten. (see Contraindications) or hepatotoxicity (see Black Box Warnings) Pancreatitis, including fatalities reported (see Black Box Warnings) Porphyria may occur. Modify Therapy/Monitor Closely. Contraindicated. CAMZYOS (mavacamten) is the first and only cardiac myosin inhibitor approved by the U.S. Food and Drug Administration (FDA) indicated for the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM) to improve functional capacity and symptoms. pentamidine. Modify Therapy/Monitor Closely. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. Cautions. Contraindications. Contraindications. metoprolol, mavacamten. Generic Name Prochlorperazine DrugBank Accession Number DB00433 Background. fluvoxamine will increase the level or effect of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. to drug/class/compon. 3 The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs. Extended release: Within 6 hr of alcohol intake; patients with metabolic acidosis that are taking metformin concomitantly. mebendazole. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. verapamil, mavacamten. Either increases effects of the other by pharmacodynamic synergism. Hypersensitivity. Generic Name Amlodipine DrugBank Accession Number DB00381 Background. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. Contraindications. It has the highest affinity for the AT 1 receptor among commercially available ARBS and has minimal affinity for the AT 2 receptor. Avoid or Use Alternate Drug. Documented hypersensitivity. Coadministration with aliskiren in patients with diabetes. propofol will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. metoprolol. brivaracetam will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Contraindications. Contraindicated. mavacamten. fluconazole will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Avoid life-threatening adverse drug events. Acute alcohol intoxication. mavacamten. 1,2. Cautions. mavacamten. verapamil, metoprolol. fluoxetine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Hypersensitivity. Narrow-angle glaucoma.

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